Literature melting point range of aspirin. Synthesis Of Aspirin Essay 2022-10-21
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Aspirin, also known as acetylsalicylic acid, is a commonly used over-the-counter pain reliever and anti-inflammatory medication. Its melting point, the temperature at which it transitions from a solid to a liquid state, is between 136-138°C. This information can be found in various scientific literature sources, such as chemistry textbooks and research articles.
Aspirin was first synthesized by a German chemist in 1897, and it has since become one of the most widely used medications in the world. It is used to relieve pain, reduce inflammation, and lower the risk of heart attack and stroke. In addition to its medicinal uses, aspirin is also used in the production of rubber, plastics, and other industrial products.
The melting point of aspirin is an important physical property that can affect its stability and effectiveness. For example, if aspirin is stored at a temperature above its melting point, it may become less stable and less effective as a medication. On the other hand, if it is stored at a temperature below its melting point, it may become more stable and have a longer shelf life.
In conclusion, the literature melting point range of aspirin is between 136-138°C. This information can be found in various scientific literature sources, and it is an important physical property that can affect the stability and effectiveness of the medication.
Experimental Synthesis of Aspirin and Melting Point Purity Analysis Donald Yeargin Essay Example
Aspirin, an acetyl derivative of salicylic acid, is a white, crystallize, weakly acidic substance, with a melting point of 136oC and a boiling point of 140oC Meyers, 2007. Potential Exposure Used as a topical keratolytic agent; in manufacture of aspirin, salicylates, resins, as a dyestuff intermediate; prevulcanization inhibitor; analytical reagent; fungicide, antiseptic, and food preservative. Unknown Crystals 532 Words 3 Pages The Identity of the unknown, in this case unknown A, was determined to be acetyl salicylic acid. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze increase the rate of chemical reactions. It is sometimes used …show more content… If the substance melts over a very narrow range, it is assumed that the substance is relatively pure. I do not even know where to start for this question. The discovery of Aspirin: a reappraisal.
This can be due to impurities of the crystals during the purification process. The median melting point temperature of the recrystallized aspirin was 131. Is aspirin acidic or basic? The active extract of the bark, called salicin, after the Latin name for the white willow Salix alba , was isolated and named by the German chemist Johann Andreas Buchner in 1826. For some people with salicylate sensitivity even these small doses can be harmful. Uses Salicylic Acid is an Impurity of Acetylsalicylic Acid A187780. NaCl was the additive that lowered the freezing point the most in the experiment.
he literature value for the melting point of aspirin is 135°C. Suppose that a sample of
Experimental results followed this expected outcome, indicating the successful synthesis of the experimental aspirin product, which maintained a lower Rf value than the reaction starting material Rf Data Figure 1. What would you expect for the melting point is this was mixed as a 50:50 mixture with pure benzoic acid melting point 121 - 122? Since the ranges for these melting points are larger than the ranges observed for the recrystalization product, it can be inferred that these samples contained impurities, and also possibly traces of ethyl acetate or water, depending on the solvent they were in. For a commercial enterprise manufacturing aspirin studies such as this one are vital to determine the most efficient processes to synthesize aspirin. Benefits for Skin Salicylic acid is a beta hydroxy acid that also sloughs dead cell buildup within the follicle, acts as a mild antibacterial, and has soothing properties. When comparing the data obtained for the crude and recrystallized aspirin samples one can conclude that steps that increase purity lead to a reduction in actual yield. Results Discussion: As discussed in the lab manual, there are certain instructions which apply to proper measurement to provide accurate values throughout the experiments. The most obvious reason for our less than perfect theoretical yield was the constant physical loss of reactants and products at each step in our synthesis scheme.
Occurrence Unripe fruits and vegetables are natural sources of salicylic acid, particularly blackberries, blueberries, cantaloupes, dates, raisins, kiwi fruits, guavas, apricots, green pepper, olives, tomatoes, radish and chicory; also mushrooms. On e of the first described NSAID drugs. J Chem Soc 3145 1954, Bergmann et al. Salicylic acid also exfoliates dead skin, and its anti-inflammatory properties make it a prime ingredient for those with psoriasis. While their extract was somewhat effective, it also caused digestive problems such as gastric irritation, bleeding, diarrhea and even death when consumed in high doses. The beaker was swirled continuously for five minutes and then submerged in a warm water bath in the temperature range of 670C-78oC for 15 minutes, where it was swirled occasionally.
The limiting reactant in this chemical reaction was salicylic acid, with acetic anhydride present in excess in order to react with any water produced during the reaction of the reactants improving the yield of aspirin. One week later, the methanol was evaporated and the experiment was completed. Ibogaine is illegal in the US however currently clinical trial approved by the FDA are in session to test how it works. It produces its anti - inflammatory effects via suppressing the activity of cyclo oxygenase COX , an enzyme which is responsible for the production of pro - inflammatory mediators such as the prostaglandins. Uses salicylic acid is a beta-hydroxy acid with keratolytic and antiinflammatory activity.
Procedure and observation The Panacetin content was weighed approximately 3. Deviations from the theoretical melting points most likely resulted from difficulties viewing and pinpointing the exact point at which the products melted in the Mel-Temp apparatus. British Medical Journal, 321. In rubber industry, it is used as anti scorching agent and production of ultraviolet absorbent and foaming agent. Another important observation is that synthesis techniques that increase the purity of a sample also lead to a decrease in percent yield. Water present in our samples would have inflated the mass of their respective samples leading to an increase in the actual yield, and thus increasing the percentage yield.
Aims: The objectives of this experiment are to carry out the process of synthesising aspirin and reinforce both the skills of recrystallisation and melting point determination. Precipitate remaining in the Erlenmeyer flask was removed by the addition of 33mL of cold water and the use of a rubber policeman. Displays anticancer effects in some solid tumors. According to the TLC analysis results, the compounds aspirin, acetaminophen, and caffeine were successfully isolated from the analgesic Excedrin tablet. Salicylic acid is used in the treatment of superficial fungal infections, acne, psoriasis, seborrheic dermatitis, warts, and other scaling dermatoses.
Acetylsalicylic acid Impurity B. It plays a role in the resistance to pathogens by inducing the production of pathogenesis-related proteins. A further objective of this experiment was to study the formation of the product phenacetin. Excedrin Synthesis Lab Report 363 Words 2 Pages Therefore, liquid-liquid and acid-base extraction techniques were successfully performed to separate the components of the Excedrin tablet. The crude product through the sublimation refined to the finished product. Safety Profile Poison by ingestion, intravenous, and intraperitoneal routes. History The Greek physician Hippocrates wrote in the 5th century BC about a bitter powder extracted from willow bark that could ease aches and pains and reduce fevers.
Processes like solubility, gravitational filtration and recrystallization will be used to separate the substances present in Panacetin. Clinical Use The clinical application of aspirin varies with the therapeutic dose. The second test to determine the purity of the sample was to mix 2. Salicylic acid is regarded to be less irritating than benzoyl peroxide and has less allergy potential, but it is also less aggressive in treating acne. Scholl's callus removers Dr.
