Phenacetin pka. What is Phenacetin?phenacetin history,shiny phenacetin,crystal phenacetin 2022-10-09
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Phenacetin is an analgesic drug, which means it is used to relieve pain. It was first synthesized in 1878 and was widely used as a pain reliever until it was banned in many countries due to its harmful side effects.
One important chemical property of phenacetin is its pKa value. pKa is a measure of the acidity of a compound, and it is important in determining how a compound will behave in solution. The pKa of a compound is the pH at which it is 50% dissociated, or ionized. A compound with a low pKa value is more likely to ionize in solution, while a compound with a high pKa value is less likely to ionize.
The pKa of phenacetin is 9.8, which is considered to be relatively low. This means that phenacetin is a weak acid, and it will ionize somewhat in solution. However, it is not as ionized as a strong acid like hydrochloric acid, which has a pKa of -7.
The pKa of phenacetin is important because it affects how the compound is absorbed in the body. When a compound is ionized, it is more likely to be absorbed through the gut and into the bloodstream. A compound with a low pKa, like phenacetin, may be more likely to be absorbed through the gut and into the bloodstream, while a compound with a high pKa may be less likely to be absorbed.
In addition to its pKa, other chemical properties of phenacetin, such as its solubility in water, also play a role in how the compound is absorbed in the body. Phenacetin is relatively soluble in water, which means it can dissolve in water and be absorbed through the gut.
Despite its effectiveness as a pain reliever, phenacetin has been linked to a number of harmful side effects, including kidney damage and an increased risk of cancer. These side effects, along with the availability of safer alternatives, led to the ban of phenacetin in many countries.
In conclusion, the pKa of phenacetin is 9.8, which is relatively low and indicates that the compound is a weak acid. The pKa of a compound can affect its absorption in the body, and phenacetin's low pKa may contribute to its absorption through the gut. However, due to its harmful side effects, phenacetin is no longer widely used as a pain reliever.
Acid dissociation constant
Ions in aqueous solution tend to orient the surrounding water molecules, which orders the solution and decreases the entropy. Includes discussion of many organic Brønsted acids. Absorption and Drug Development: Solubility, Permeability, and Charge State. Archived from PDF on 24 September 2015. This will ensure that p K a remains invariant during the titration. Items to prepare: some phenacetin powder, stainless steel spoon, lighter or alcohol lamp for heating 2.
Phenacetin: Uses, Interactions, Mechanism of Action
Metabolism Metabolised in the body to paracetamol. } When a reactant undergoes two reactions in series, the macroconstant for the combined reaction is the product of the microconstant for the two steps. General chemistry: principles and modern applications 8thed. Amsterdam, The Netherlands: Elsevier. . .
What is Phenacetin?phenacetin history,shiny phenacetin,crystal phenacetin
Involved in the constitutive production of prostanoids in particular in the stomach and platelets. Data at 25°C from Pine et al. It was listed in the United States in 1887. Many applications exist in K a values of proteins and K a values cannot always be measured directly, but may be calculated using theoretical methods. We only need to wait for one or two minutes. The nature of the chemical bond and the structure of molecules and crystals; an introduction to modern structural chemistry 3rded.
This ratio is independent of the analytical concentration of the acid. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Instead, the p K a of the conjugate acid, denoted by p K aH, is quoted when basicity needs to be quantified. Gene Name CYP2A13 Uniprot ID Uniprot Name Cytochrome P450 2A13 Molecular Weight 56687. The buffer regions carry the information necessary to get the p K a values as the concentrations of acid and conjugate base change along a buffer region.
Computational Methods for the Determination of Formation Constants. . This reaction is quantitative and hence can be ignored in the context of chemical equilibrium. The data were critically selected and refer to 25°C and zero ionic strength, in water. Gene Name CYP1A2 Uniprot ID Uniprot Name Cytochrome P450 1A2 Molecular Weight 58293. While it is considered a prescription drug, no marketed drugs contain phenacetin. Ion Exchange and Solvent Extraction: A Series of Advances.
Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-s. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. The metabolism of Phenacetin can be decreased when combined with Acetohexamide. These are organic compounds containing an acetamide group conjugated to a phenyl group. In addition, the metal ion is subject to K values for the hydrolysis reactions must also be known.
Gene Name CYP2D6 Uniprot ID Uniprot Name Cytochrome P450 2D6 Molecular Weight 55768. Archived from PDF on 30 October 2014. Journal of the Optical Society of America A. Since the proton carries a positive charge extra work is needed to remove it. Data presented here were taken at 25°C in water. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity 1968 to 1987 N Engl J Med. The same is true of p K a values obtained in a particular non-aqueous solvent such a DMSO.
K value of ca. A REPORT ON TWENTY-THREE USERS OF THE DRUG. HPLC: if the former two detection methods are to detect whether phenacetin is correct, then HPLC is to determine whether phenacetin is good or bad, because it is used to detect phenacetin purity. A p K a value obtained in a mixed solvent cannot be used directly for aqueous solutions. Mechanism of action Target Actions Organism U Not Available Humans Absorption Not Available Volume of distribution Not Available Protein binding Not Available Metabolism Metabolised in the body to paracetamol. A REPORT ON TWENTY-THREE USERS OF THE DRUG. It performs a variety of oxidation react.
The serum concentration of Phenacetin can be increased when it is combined with Abiraterone. It is an antipyretic, acting on the brain to decrease the temperature set point. Acids and bases are thus regarded simply as donors and acceptors of protons respectively. These facts are obscured by the omission of the solvent from the expression that is normally used to define p K a, but p K a values obtained in a given mixed solvent can be compared to each other, giving relative acid strengths. . The case of citric acid is shown at the right; solutions of citric acid are buffered over the whole range of pH2.