Cerebrospinal fluid (CSF) is a clear, colorless fluid that surrounds the brain and spinal cord. It plays a number of important roles in the body, including cushioning and protecting the brain and spinal cord, removing waste products from the brain, and maintaining a constant pressure around these vital organs. One of the key components of CSF is chloride, which is an electrolyte that helps to regulate the balance of fluids in the body.
Chloride is an anion, or negatively charged ion, that is formed when chlorine gains an extra electron. It is an essential component of the body's electrolyte balance, as it helps to regulate the pH of the body's fluids. Chloride is found in a number of body fluids, including blood, sweat, and urine, and it is also an important component of CSF.
In CSF, chloride plays a number of important roles. It helps to regulate the pH of the fluid, which is important for maintaining the proper function of the brain and spinal cord. Chloride also helps to remove waste products from the brain, as it is involved in the process of osmosis, which helps to filter out toxins and other unwanted substances from the brain.
Chloride levels in CSF can be measured through a test known as a CSF chloride test. This test is typically used to diagnose certain medical conditions, such as meningitis, a brain tumor, or a brain abscess. Abnormal levels of chloride in CSF can also be a sign of other health problems, such as dehydration or kidney disease.
It is important to maintain the proper balance of chloride in CSF, as an imbalance can lead to a number of health problems. For example, high levels of chloride in CSF can cause an electrolyte imbalance, which can lead to muscle weakness, fatigue, and other symptoms. Low levels of chloride in CSF can also cause problems, as it can lead to a decrease in the body's ability to remove waste products from the brain, which can lead to a buildup of toxins and other harmful substances.
Overall, chloride is an important component of CSF, and it plays a number of important roles in maintaining the health and function of the brain and spinal cord. Proper levels of chloride in CSF are essential for maintaining the body's electrolyte balance and for removing waste products from the brain.
Significance of chloride contents in cerebrospinal fluid and plasma and their ratio in early diagnosis and differential diagnosis of central nervous system infections
If the sample is collected in three tubes, all the tubes will be the same color. Davidson's principles and practice of medicine 21sted. CSF test, in conjunction with the blood or urine test , can help evaluate your current medical condition. The test lasts for less than half an hour. Textbook of medical physiology 11thed. The chloride contents in plasma declined more markedly in cryptococcal meningitis patients than in those with tuberculous meningitis and viral meningitis. The patient will have to either lie down in a fetal position or a normal sitting position.
What are the preparations required before the test? Methods The chloride contents in CSF and plasma were detected from Jan. Dr Lincoln taught otherwise; her studies showed that low CSF chloride values simply reflected total-body chloride depletion and hypochloremia secondary to prolonged vomiting. CSF chloride is cheap readily available non-invasive investigation which could aid thephysician in clearly differentiating the bacterial and other causes of meningitis. In an era when tuberculous meningitis was a common CNS infection, classic teaching held that a low CSF chloride value was almost pathognomonic of this severe disease. Fluids and Barriers of the CNS. Conclusion Although initially daunting, obvious patterns will become recognisable.
In low blood chloride level. We were told that CSF glucose and protein determinations were helpful in assessing the course of tuberculous meningitis but that CSF chloride determination was worthless. CPT Codes The American Medical Association Current Procedural Terminology CPT codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. National Institute of Neurological Disorders and Stroke. Whereas, yellow, orange or brown, sample may indicate the presence of a higher amount of CSF protein. Clinical Methods: The History, Physical, and Laboratory Examinations 3rded.
RESULTS: In our study, the mean value of CSF chloride in bacterial meningitis was found to be 117. CSF test is dangerous if you have low platelet count in blood, blood clotting disorder, or tumour at the back of your brain. The Human Nervous System. CSF proteins comparison with serum proteins: Type of protein Concentration in the serum Concentration in the CSF Prealbumin 23. The spinal fluid is the apt sample that can be used to diagnose conditions that affect your central nervous system since the fluid surrounds and protects both your brain and spinal cord. European Journal of Pediatrics. Item Type: Thesis Masters Uncontrolled Keywords: Meningitis, CSF chloride, Differentiation.
A Study of Cerebrospinal Fluid Chloride Levels in Meningitis
The present study aims at determining whether CSF chloride could aid in differentiating meningitis etiologically. Results The chloride contents of CSF and plasma sample and the ratio of CSF to plasma chlorides decreased in tuberculous meningitis group 101. Reference values vary based on several factors, including the specific laboratory that supplies them. The most important of these are given in the below note that these are for adults only. When you are experiencing a combination of symptoms along with fever and flu-like symptoms.
What is the normal volume of CSF? The healthcare provider will insert a spinal needle into your spinal canal, and the opening pressure reading is taken. The chloride content in CSF was significantly lower in tuberculous meningitis and cryptococcal meningitis patients than in viral meningitis patients. Procedure Steps The most important knowledge to have for this station are the normal values. As the forebrain develops, the neural cord within it becomes a ventricle, ultimately forming the lateral ventricles. ARUP Laboratories assumes no responsibility for billing errors due to reliance on the CPT codes published. An intricate network of cells called Choroid plexus secretes Cerebrospinal fluid.
OBJECTIVES: To substantiate already available investigations in aiding presumptive diagnosis of meningitis. Lymphatic Research and Biology. Now the third tube will be clear or less in color. CSF moves in a single outward direction from the ventricles, but multidirectionally in the subarachnoid space. Functional Anatomy and Physiology of Domestic Animals. For instance, clopidogrel, warfarin and over the counter pain relievers like naproxen sodium, ibuprofen, or aspirin. Objective To evaluate the significance of the chloride contents both in cerebrospinal fluid CSF and plasma, and the ratio of two chloride contents in early diagnosis and differential diagnosis of central nervous system infections.
The total volume of CSF in adults ranges from 90 to 150mL, whereas 10 to 60 mL in infants. If any result is abnormal, it should be commented whether the result is slightly or very deranged. If the CSF test results come back normal, then it means that there is nothing abnormal found within the cerebrospinal fluid. You will be asked to lie down, without lifting your head for an hour or more after the test. It brings the entire family together for emotional support and understanding across multiple locations to reach you in the community where you live.
Spinal Fluid Chloride: A Test 40 Years Past Its Time
European Annals of Otorhinolaryngology, Head and Neck Diseases. The changes in various conditions are given below. Besides lumbar puncture, ventricular puncture or cisternal puncture are also used for collecting CSF samples. CSF chloride levels are estimated in all the study subjects. Decreased Chloride is seen in: Bacterial meningitis.