Synthesis of aspirin equation. Synthesis of aspirin equation 2022-10-02

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Aspirin, also known as acetylsalicylic acid, is a common over-the-counter pain reliever and anti-inflammatory medication. It is used to treat a variety of ailments, including headaches, muscle pain, and fever. Aspirin is synthesized through a chemical reaction known as esterification, which involves the combination of a carboxylic acid and an alcohol. The synthesis of aspirin involves the following equation:

Reactants:

Products:

The synthesis of aspirin begins with the reactant salicylic acid, which is derived from plants such as willow trees and meadowsweet. Salicylic acid is a natural compound that has been used for centuries to treat a variety of ailments, including pain and inflammation.

Next, the reactant acetic anhydride is added to the salicylic acid. Acetic anhydride is a chemical compound that is used as a reagent in the synthesis of various organic compounds, including aspirin.

Phosphoric acid is added as a catalyst to speed up the reaction between the salicylic acid and acetic anhydride. The combination of these reactants results in the production of aspirin, also known as acetylsalicylic acid, and acetic acid.

The synthesis of aspirin is an important chemical reaction that has numerous applications in the medical field. Aspirin is a widely used pain reliever and anti-inflammatory medication that is effective in treating a variety of ailments. The synthesis of aspirin involves the combination of a carboxylic acid and an alcohol through the process of esterification, resulting in the production of acetylsalicylic acid and acetic acid.

Synthesis of aspirin equation

synthesis of aspirin equation

Allow the mixture to cool to near room temperature. Conduct this reaction in a fume hood. How does the melting temperature test of your aspirin compare to the accepted value? Add 10 mL of ethanol to the beaker of aspirin sample. Therefore the balance did not have a very good precision and would give a percentage error in the reading. Both substances can cause painful burns if they come in contact with the skin. Do reaction using 90% of that salicylic acid.

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Experiment_614_Synthesis of Aspirin_1_1_2

synthesis of aspirin equation

MSDS are available from the 2507 webpage. The theoretical yield of aspirin is 2. Gently transfer the filter paper with your product onto the watch glass to air dry. The original data and obtained data are revealed, and then they are discussed with thorough interpretations along with conclusions made, as well as recommendations. This is a substitution reaction in which an alcohol the —OH group in salicylic acid reacts with acetic anhydride to form an ester, aspirin. The chemical reaction involved in this entire process is given below: Aspirin is the first Non-Steroidal Anti-Inflammatory Drug NSAID that was discovered. Upon completion of the lab, analysis, and calculations, it is evident that the synthesis of aspirin is possible using these methods but that the yield will be relatively low.


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Chemical Equation Synthesis Of Aspirin

synthesis of aspirin equation

The search for a milder form of this pain reliever led to the successful synthesis of acetylsalicylic acid by the German chemist Felix Hoffmann in 1893. It was hard to see the figures and it was old and had scratches on the panel. Avoid contact with your eyes, skin, and clothing. Chill for at least 10 minutes in order to obtain the maximum amount of crystalline product. The report then approaches to the hazards and risk analysis of the chemicals involved in the experiment and how precautions are taken to reduce these risks. HCl in 10 mL of water in a 150-mL beaker and cool the mixture in an ice bath.

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Synthesis of Acetyl Salicylic Acid (Aspirin) Essay Example

synthesis of aspirin equation

It was not digital and did had a disk shaped scale. After all of the water was filtered through, left the filter paper to dry until the next class. Transferred the salicylic acid to a 50 mL Erlenmeyer flask. If you have any queries about this page or, in general, about the aspirin formula, ping us through the comment box below, and we will get back to you as soon as possible. To determine the concentration of the salicylic acid impurity in the treated aspirin sample, interpolate along the regression line to convert the absorbance value of the unknown to concentration.

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Synthesis Of Aspirin Lab Report [vnd5ppm7k5lx]

synthesis of aspirin equation

The ortho regiochemistry is favored over para by coordination of the incoming CO2 by the sodium cation. If acetylsalicylic acid does not begin to crystallize out, scratch the walls of the flask with a glass rod. Ex: A+B " C! Transfer 90% of salicylic acid into a 50 mL Erlenmeyer flask 3. Reacts sometimes delayed violently with water. Obtain mass of dry salicylic acid. Corrected for purity, is: 1. The findings showed that acetylsalicylic acid can be produced through a reaction between salicylic acid and acetic anhydride, but that a much lower yield will be produced.


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The Chemistry of Aspirin

synthesis of aspirin equation

Quantitatively transfer the solution from the beaker to a 250 mL volumetric flask. Bring the solution to a boil quickly and limit the amount of time you are boiling the crystals in the solvent 9. What is the yield of aspirin? Make sure that the resulting solution is acidic blue litmus paper and that the aspirin has completely precipitated out. Weighed a piece of filter paper and recorded it on the data sheet. It can also inhibit urate secretion and should be avoided in gout 3. How a warehouse of ammonium nitrate destroyed a capital city.


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Organic synthesis of Aspirin from benzene

synthesis of aspirin equation

This proves that the aspirin that had been made in the experiment was not 100% pure and contained some impurities. The powder funnel is placed in a ring and has a filter paper cone inside -The hot solvents contains insoluble material -Vacuum filtration is used for high-boiling organics alcohol and hydrocarbon solvents and water -Use a Buchner funnel. Human error was also taken into account Time Other problems also included time factor. Note: no more then 0. As the yield is produced its melting point will be found, and it will be compared to values of aspirin that have been stated in chemical textbooks. Any information that is included in the report will be referenced at the end.

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Lab B

synthesis of aspirin equation

Therefore this could also be a reason as to why the yield was not accurate and also explain why there was a significant difference in the temperatures. Rinsed the dirty apparatus thoroughly with lots of water. Aspirin acetylsalicylic acid is the most common medicinal drug in use today. The absorbance of 0. Aspirin binds to and acetylates serine an amino acid used by the body to make proteins residues in the active site of cyclooxygenase enzymes, leading to reduced production of prostaglandin.

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