The Grignard reaction is a chemical reaction in which an alkyl, vinyl, or aryl magnesium halide (Grignard reagent) reacts with a carbonyl compound to form a new carbon-carbon bond. The resulting product is an alcohol, and the process is called the Grignard synthesis of alcohols. One common example of the Grignard reaction is the synthesis of triphenylmethanol from benzophenone and magnesium.
In the laboratory, the Grignard reaction is typically carried out in a round-bottom flask equipped with a reflux condenser. The Grignard reagent, which can be synthesized from the reaction of an alkyl or aryl halide with magnesium metal, is added to the flask along with a small amount of dry ether. The carbonyl compound, in this case benzophenone, is then added to the flask, and the mixture is heated under reflux until the reaction is complete.
During the Grignard reaction, the Grignard reagent acts as a nucleophile, attacking the carbonyl carbon of the benzophenone and forming a new carbon-carbon bond. The resulting product is an intermediate, which can then be treated with aqueous acid to yield the final product, triphenylmethanol.
In addition to its use in the synthesis of alcohols, the Grignard reaction is also useful for the preparation of a variety of other organic compounds, including carboxylic acids, amines, and even ketones. It is an important tool in the synthetic organic chemist's toolkit and has been widely used in the pharmaceutical industry and other areas of organic synthesis.
Overall, the Grignard reaction is a powerful and versatile synthetic method for the preparation of alcohols and other organic compounds. Its success in the laboratory and in industry is a testament to its utility and importance in the field of organic chemistry.
Lab 12_ Grignard Reaction
Because the reaction is moisture sensitive, all glassware was oven- dried before use and a drying tube was employed. In this case, the electrons on the negatively charged oxygen atom are used to reform the carbonyl pi bond, thereby forcing the C-N or C-O bond of the ester, amide, or anhydride to detach as a leaving group generating a ketone intermediate. The peak at about 82ppm corresponds with the carbon bonded to the alcohol functional group. Email the digital photographs to me at acarrawa meridiancc. The triphenlmethanol was then isolated and purified by crystallization and vacuum filtration.
Lab Report 7
Department of Labor, nor does mention of trade names, commercial products, or organizations imply endorsement by the U. The TLC analysis furthermore corresponded with our results as it only showed one spot for the product indicating that it is in fact pure. Bromobenzene was first mixed with magnesium and anhydrous ether in a flask. Palladium typically exists in the oxidation states of 0, +2, and +4. The peak at about 7. An additional 10ml of ether was added to the flask using a glass funnel.
Grignard Synthesis Lab Report
The purpose of this experiment was to synthesize triphenylmethanol from a Grignard reagent. Since the Grignard reagent can behave like a strong base, there should not be any water, otherwise the reaction would not proceed or create undesired products. Any Physical Data for Reagents and Instruments Procedure First, all of the glassware was dried and cooled to room temperature, then 0 g of Mg and 10 mL anhydrous ether were added to a round 25 mL round bottom flask. The condenser was then turned on and the reaction mixture gently refluxed for 25minutes. The triphenylmethanol was characterized using IR spectroscopy, NMR, and Thin Layer Chromatography.
