Preparation of aspirin from salicylic acid. Aspirin (Synthesis and Mechanism) 2022-10-17

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Aspirin is a commonly used pain reliever and anti-inflammatory medication. It is also known as acetylsalicylic acid, and is derived from salicylic acid, a compound found in plants such as willow trees. The preparation of aspirin involves a chemical reaction between salicylic acid and acetic anhydride, with the addition of a small amount of sulfuric acid as a catalyst.

To prepare aspirin, the following materials and equipment are needed:

The first step in preparing aspirin is to measure out the appropriate amounts of salicylic acid and acetic anhydride. These two compounds are mixed together in a beaker, along with a small amount of sulfuric acid as a catalyst. The mixture is then stirred thoroughly with a stirring rod to ensure that the compounds are well combined.

Next, the mixture is transferred to a flask, and heated over a Bunsen burner until the reaction is complete. The temperature of the mixture should be kept at around 70-80°C, and the reaction should be allowed to continue for about an hour.

After the reaction is complete, the mixture is allowed to cool and then filtered through a piece of filter paper. The resulting solid product is aspirin, which can be collected by pressing it out of the filter paper using a glass funnel.

It is important to note that the preparation of aspirin requires careful handling of chemicals, as some of the compounds used are potentially dangerous. Proper protective equipment, such as goggles and gloves, should be worn at all times during the preparation process.

Overall, the preparation of aspirin from salicylic acid is a simple chemical reaction that can be easily carried out in a laboratory setting. The resulting product, acetylsalicylic acid, is a widely used pain reliever and anti-inflammatory medication that is effective in reducing the symptoms of various conditions such as headache, fever, and inflammation.

Preparation of Acetyl Salicylic Acid (Aspirin) Lab Report

preparation of aspirin from salicylic acid

Aspirin is non-narcotic i. REQUIREMENTS Chemicals: Salicylic acid — 10 g Pyridine — 7 ml Acetyl chloride — 7. For synthesising aspirin, we first need to prepare salicylic acid. While, when aspirin is tested with ferric acid, no colour will form because it is not a phenol. The product is obtained as colourless crystals, yield 11 g and m.

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S11195638 CH102 Preparation of Aspirin (Acetyl salicylic acid)

preparation of aspirin from salicylic acid

To generate a purple complex, iron III ions combine with phenols. Set the product to dry. Air dry the crystals and transfer them to a watch glass to dry. As the kinetic energy increase, molecules move faster and collide with other molecules, therefore there are more interactions. You can use some of the filtrate to rinse the Erlenmeyer flask if necessary.


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Synthesis of Acetyl Salicylic Acid (Aspirin) Essay Example

preparation of aspirin from salicylic acid

Salicylic acid is ortho-hydroxybenzoic acid. Note: All the above reactions are taking place in an aqueous medium. . Notice that salicylic acid contains the phenol functional group but aspirin does not. Do this test with 1.

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Aspirin (Synthesis and Mechanism)

preparation of aspirin from salicylic acid

Discussion and Interpretation Analysing the results obtained it is clear that the experiment was a success. Test this crude product for the presence of unreacted salicylic acid using the ferric chloride test. This will be the catalyst for the reaction. Vacuum filtration will be used to collect solid aspirin. After completing the aspirin synthesis, two tests were conducted to establish the relative purity of the aspirin we produced. The report then approaches to the hazards and risk analysis of the chemicals involved in the experiment and how precautions are taken to reduce these risks. .

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The reagent(s) used in the preparation of aspirin from salicylic acid is: (a) ${ SOCl }_{ 2 }$, pyridine(b) ${ (CH }_{ 3 }CO{ ) }_{ 2 }O$, ${ H }^{ + }$(C) ${ CH }_{ 3 }{ CO }_{ 2 }H$, HCl(d) ${ CH }_{ 3 }Cl$, $Al{ Cl }_{ 3 }$

preparation of aspirin from salicylic acid

The Organic Chemistry of Biological Pathways by John McMurry and Tadhg Begley Roberts and Company, 2005 "8. This will be done by subtracting the mass of the dry weight by the mass of the beaker. Any information that is included in the report will be referenced at the end. They are classified as non-narcotic or narcotic pain relievers. As the report progresses the answers to the hypothesis become clear. From analysing the original data values it is possible to calculate the theoretical yield using moles and masses. .

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1: Synthesis of Aspirin (Experiment)

preparation of aspirin from salicylic acid

The solution in the flask was then poured into a 150-mL beaker containing 20mL of ice water and mixed thoroughly before placing the beaker in an ice bath. Write a balanced equation to show the above reaction. It is recommended for arthritis and related arthritic conditions, myocardial infarction prophylaxis. As the temperature of the water increases, the solubility of aspirin increases due to an increased amount of interactions and collisions. From this point on, keep your flask under the hood, because it now contains acetic anhydride the vapors of acetic anhydride are very irritating. Gloves were used to ensure chemicals did not come in contact with the skin as chemicals could enter the body through broken skin. It was not digital and did had a disk shaped scale.


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Synthesis of aspirin from salicylic acid using acetyl chloride and pyridine

preparation of aspirin from salicylic acid

Organic Chemistry at CU Boulder. The end product i. Temperature will be one of the hardest aspects to control; the quality of the experiment heavily lies on this. Can you predict how these groups affect the properties of the molecule and how the body reacts? The acid part of the molecule is one of the factors that causes stomach irritation. To determine actual yield of acetylsalicylic acid isolated.

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Experiment_614_Synthesis of Aspirin_1_1_2

preparation of aspirin from salicylic acid

Vacuum filtration will be used to collect solid aspirin. Salicylic acid was neutralized with sodium to produce sodium salicylate, which tasted better but still irritated the stomach. Although the salicin in willow bark has analgesic properties, the purified salicylic acid was bitter and irritating when taken orally. Sulphuric acid or phosphoric acid will be used as a catalyst. Its analgesic, antipyretic, and anti-inflammatory properties make it a powerful and effective drug to relive symptoms of pain, fever, and inflammation.

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