Phenylethylamine, also known as beta-phenylethylamine or PEA, is a naturally occurring compound found in the human body and in a variety of plants. It is classified as a trace amine, meaning it is present in very small amounts in the body. PEA is produced in the brain and is thought to play a role in the regulation of mood, attention, and motivation.
PEA has been shown to have a number of potential health benefits. It has been studied for its effects on mood and cognition, and it has been suggested that it may have antidepressant and anti-anxiety effects. PEA has also been shown to have neuroprotective properties and may be able to protect the brain from damage caused by toxins and inflammation.
PEA is found in a variety of foods, including chocolate, cheese, and wine. It is also available as a dietary supplement, though the safety and effectiveness of these supplements have not been fully studied. Some people use PEA supplements as a way to enhance their mood or cognitive function, though there is limited scientific evidence to support these claims.
There are some potential side effects associated with PEA supplementation. It may cause increased heart rate and blood pressure, as well as restlessness and anxiety. PEA may also interact with certain medications, including antidepressants and stimulants, and may cause adverse reactions when taken in combination with these drugs.
In conclusion, PEA is a naturally occurring compound found in the human body and in certain foods. It has been suggested to have a number of potential health benefits, including effects on mood and cognition, as well as neuroprotective properties. However, more research is needed to fully understand the safety and effectiveness of PEA, particularly when taken as a dietary supplement. It is important to speak with a healthcare provider before starting any new supplement, including PEA, to ensure it is safe and appropriate for your individual needs.
Sabelli H, Fink P, Fawcett J, et al. Do NOT induce vomiting. European Journal of Pharmacology. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. . . J Neuropsychiatry Clin Neurosci.
A renaissance in trace amines inspired by a novel GPCR family. Phenylethlyamine modulation of affect: therapeutic and diagnostic implications. Some of these medications used for depression include phenelzine Nardil , tranylcypromine Parnate , and others. Figueiredo T, Viegas R, Lara L, et al. IF SWALLOWED: Rinse mouth. P264 : Wash skin thoroughly after handling.
PHENETHYLAMINE (PEA): Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews
P303 + P361 + P353 : IF ON SKIN or hair : Take off immediately all contaminated clothing. Pessione E, Pessione A, Lamberti C, et al. This stereoselective N-oxygenation to the trans-oxime is also seen in the FMO-dependent N-oxygenation of amphetamine Cashman et al. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. Antelman SM, Edwards DJ, Lin M. Phenethylamine: evidence for a direct, postsynaptic dopamine-receptor stimulating action. Szabo A, Billett E, Turner J.
Although we did not find a sufficient number of studies suitable for a meta-analysis of PEA and ADHD, three studies 20,57,58 confirmed that urinary levels of PEA were significantly lower in patients with ADHD compared with controls. . Minchin RF, Barber HE, Ilett KF. Retrieved 10 November 2014. Endogenous extracellular tissue levels of trace amines measured in the brain are in the low nanomolar range. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse.
Xie Z, Miller G. Beck O, Helander A, Karlson-Stiber C, et al. GC Infrared Spectrum Authentic Linear Formula C 6H 5CH CH 3 NH 2 Beilstein 12,II,587 Packaging Glass bottle Fieser 09,363; 13,185; 17,276; 12,319; 11,411; 05,441; 03,199; 01,838; 02,271; 08,393 Merck Index 13, 6054 Refractive Index 1. Singhal AB, Caviness VS, Begleiter AF, et al. Sabelli HC, Javaid JI.
You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. J Neuropsychiatry Clin Neurosci. An α-methyl group on the side chain, as in amphetamine and ephedrine, renders the amine immune to deamination so that they are not metabolized in the gut. Sabelli H, Fink P, Fawcett J, et al. Increased stress response and beta-phenylethylamine in MAOB-deficient mice.
J Pharmacol Exp Ther. . Furthermore, considering the structural and pharmacological analogy between amphetamines and phenylethylamine, it is conceivable that phenylethylamine plays a role in the commonly reported "runners high" thought to be linked to cerebral β-endorphin activity. Do NOT induce vomiting. The increases were delayed in most subjects and were not correlated with changes in urinary pH or creatinine excretion. Granvogl M, Bugan S, Schieberle P. As reported for TAAR1 in HEK cells Bunzow et al.
Tyramine and phenylethylamine biosynthesis by food bacteria. Crit Rev Food Sci Nutr. Harmful in contact with skin. Shannon H, Cone E, Yousefnejad D. Trends in Pharmacological Sciences. Paterson I, Juorio A, Boulton A. Some medications used for depression also increase serotonin.
Physiologic effects and plasma kinetics of beta-phenylethylamine and its N-methyl homolog in the dog. Naunyn-Schmiedeberg's Archives of Pharmacology. The urinary excretion rate of the endogenous, amphetamine-like substance beta-phenethylamine was markedly elevated in human subjects in association with an initial parachuting experience. Crit Rev Food Sci Nutr. Whitehouse Station, NJ: Merck and Co. These results show substantial increases in urinary phenylacetic acid levels 24 hours after moderate to high intensity aerobic exercise.
Acta 834 , 58-66, 2014 A new procedure for determination of biogenic amines BA : histamine, phenethylamine, tyramine and tryptamine, based on the derivatization reaction with 2-chloro-1,3-dinitro-5- trifluoromethyl -benzen. Sustained antidepressant effect of PEA replacement. J Pharmacol Exp Ther. Presence of phenylethylamine in hallucinogenic Psilocybe mushroom: possible role in adverse reactions. .